なさる
nasaru
The word that slides a pedestal under someone's する
The picture A pedestal slid under whatever the other person does, lifting it one level, with you looking up at it from below. なさる puts their する on a pedestal; いたす lowers your own する to knee height.
Where the picture shows up in なさる
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a departure on the pedestal
社長は何時に出発なさいますか。
shachō wa nanji ni shuppatsu nasaimasu ka
What time will you be departing?
The president's departure time lifted onto a pedestal, set on a shelf one level up, looked at from below.
It attaches straight onto a する-noun (出発なさる); put ご on the noun for one more notch (ご予約なさる).
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reading what happened to them
どうなさいましたか。顔色が悪いですよ。
dō nasaimashita ka. kaoiro ga warui desu yo
What seems to be the matter? You look pale.
Whatever has happened to them lifted carefully, pedestal and all, while you study their face.
The fixed opening line in a clinic or a shop when asking what's wrong.
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asking whether it's already done
ご予約はなさいましたか。
go-yoyaku wa nasaimashita ka
Have you made a reservation?
The act of reserving placed in their high slot, and you checking whether that slot is full or empty.
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catching the hand on the pedestal
どうぞ無理はなさらないでください。
dōzo muri wa nasaranaide kudasai
Please don't overdo it.
The hand still working up on the pedestal caught gently and set back down.
なさらないでください is the default when stopping someone or expressing concern.
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a whole day spread on the pedestal
休みの日は何をなさっているんですか。
yasumi no hi wa nani o nasatte iru n desu ka
What do you do on your days off?
Their entire day off spread out across the pedestal while you look at it from underneath.
All of it in one picture
なさる changes only する, and whatever noun stands in front of it rides up too. Put 出発 or 予約 there and the whole action goes onto the pedestal; ask what has happened and you lift the event itself, pedestal and all, to read their face. Stopping them, you gently catch the hand moving up there and set it down; asking what they do on days off, you spread that whole day across the pedestal and look at it from underneath.